Student presenter in front of poster

PUBLICATIONS

AY 19-20

Roberts, K. M.; Connor, G. C.*; Cave, H*.; Rowe, G. T.; Page, C. A.  “The metal- and substrate-dependences of 2,4’-dihydroxyacetophenone dioxygenase” Archives of Biochemistry and Biophysics, 2020, 691, 108441. http://doi.org/10.1016/j.abb.2020.108441

Marshall, N; Rodriguez, A.* Cross-coupling polymerization at iodophenyl thin films prepared by spontaneous grafting of a diazonium salt" PeerJ Mat. Sci., 2020, 2, e6

Schneider, J. D.; Smith, B. A.*; Williams, G. A.; Powell, D. R.; Perez, F.; Rowe, G. T.; Yang, L. “Synthesis and Characterization of Cu(II) and Mixed-Valence Cu(I)Cu(II) Clusters Supported by Pyridylamide Ligands” Inorganic Chemistry, 2020, 59, 5433-5446. http://doi.org/10.1021/acs.inorgchem.0c00008

Marshall, N.; James, W.*; Fulmer, J.*; Crittenden, S.; Thompson, A. B.; Ward, P. A.; Rowe, G. T.  “Polythiophene Doping of the Cu-Based Metal-Organic Framework (MOF) HKUST-1 Using Innate MOF-Initiated Oxidative Polymerization” Inorganic Chemistry, 2019, 58, 5561-5575. http://doi.org/10.1021/acs.inorgchem.8b03465

AY 17-18

Marshall, N; Rodriguez, A;* Crittenden, S. "Diazonium-functionalized thin films from the spontaneous reaction of p-phenylenebis(diazonium) salts." RSC Advances, 2018, 8, 6690-6698.

Roberts, K. M., Fitzpatrick, P. F. Measurement of kinetic isotope effects in an enzyme-catalyzed reaction by continuous-flow mass spectrometry. Methods Enzymol. 2017, 596, 149-161. http://doi.org/10.1016/bs.mie.2017.07.001

AY 16-17

Taylor, A. B., Roberts, K. M., Coa, X., Clark, N. E., Holloway, S. P., Donati, E., Polcaro, C. M., Pica-Mattoccia, L., Tarpley, R. S., McHardy, S. F., Cioli, D., LoVerde, P. T., Fitzpatrick, P. F., Hart, P. J. Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy. J Biol. Chem. 2017, 292(27), 11154-11164. http://doi.org/10.1074/jbc.M116.766527

Clark, N. E., Katolik, A., Roberts, K. M., Taylor, A. B., Holloway, S. P., Schuermann, J. P., Montemayor, E. J., Stevens, S. W., Fitzpatrick, P. F., Damha, M. J., Hart, P. J. Metal dependence and branched RNA co-crystal structures of the RNA lariat debranching enzyme Dbr1. PNAS USA 2016, 113(51), 14727–14732. http://doi.org/10.1073/pnas.1612729114

McMoran, E. P.; Powell, D. R.; Perez, F.; Rowe, G. T.; Yang, L. “Synthesis and Characterization of Copper Complexes with CuICuI, Cu1.5Cu1.5, and CuIICuII Core Structures Supported by a Flexible Dipyridylamide Ligand” Inorganic Chemistry, 2016, 55, 11462-11472. http://doi.org/10.1021/acs.inorgchem.6b02006

McMoran, E. P.; Dominguez, M. N.*; Erwin, E. M.; Powell, D. R.; Rowe, G. T.; Yang, L.  “Structural diversity, spectral characterization and computational studies of Cu(I) complexes with pyridylamide ligands.”  Inorganica Chimica Acta, 2016, 446, 150-160.  https://doi.org/10.1016/j.ica.2016.03.011

AY 15-16

Choony, N.; Rowe, G. T.; Choony, C. D.*; Earhart, L. S.*; Fulmer, J. M.*; Johnson, D.*; Loveless, T. M.*  “The Use and Thermodynamic Origin of the Trityl Buttress Effect in Intramolecular Diels-Alder Cycloaddition Reactions.” Current Organic Synthesis, 2016, 13(4), 617-622. http://dx.doi.org/10.2174/1570179413666151218203401

Pauly, M. A.; Erwin, E. M.; Powell, D. R.; Rowe, G. T.; Yang, L.  “A Synthetic, Spectroscopic and Computational Study of Divalent Metal Complexes Supported by Pyridylamide Ligands” Polyhedron. 2015, 102, 722-734.  https://doi.org/10.1016/j.poly.2015.11.015

Fitzpatrick, P. F., Chadegani, F., Zhang, S., Roberts, K. M., Hinck, C. S. Mechanism of the flavoprotein L-hydroxynicotine oxidase: kinetic mechanism, substrate specificity, reaction product, and roles of active-site residues. Biochemistry 2016, 55(4), 697–703. http://doi.org/10.1021/acs.biochem.5b01325


PRESENTATIONS

*denotes undergraduate researchers

AY 19-20

Roberts, K. M. Oxidation by DAD: A novel reaction or an old dog with new tricks? Department of Chemistry Graduate Seminar (University of Georgia, Athens, GA; October 10, 2019) – Invited Talk  

White, D. W., Laboratory Studies of Thermally Processed Ice Mixtures Relevant to Outer-Planetary Surfaces.  Southeastern Regional Meeting of the American Chemical Society (SERMACS), Savannah, GA.  Oct. 22, 2019.

AY 18-19

Burgess, T. F.*, Foss, K. L.*, White, D. W.  Laboratory Studies of Astrochemical Ice Mixtures. Discover USC (Columbia, SC; April 26, 2019) - Poster

Roberts, K. M. Oxidation by DAD: A novel reaction or an old dog with new tricks? Paul F. Fitzpatrick Retirement Symposium: Enzymes: From Isotope Effects to Allostery (University of Texas Health Science Center, San Antonio, TX; April 27, 2019) – Invited Talk          

Roberts, K. M. Oxidation by DAD: A novel reaction or an old dog with new tricks? ACS-Savannah Research Site Local Section Spring 2019 Dinner Meeting (Aiken, SC; March 8, 2019) – Invited Talk

Cave, C. H.*, Connor, G. C.*, Rowe, G. T., and Roberts, K. M. Substrate Binding in 2,4’-Dihydroxyacetophenone Dioxygenase (DAD). 26th Enzyme Mechanism Conference (New Orleans, LA; January 6-9, 2019) – Poster

Roberts, K. M. Oxidation by DAD: A novel reaction or an old dog with new tricks? Southeast Regional Meeting of the American Chemical Society 2018 (Augusta, GA; November 1, 2018) – Section Talk and Host

Cave, C. H.*, Connor, G. C.*, Rowe, G. T., and Roberts, K. M. Structural insights into substrate binding by 2,4’-dihydroxyacetophenone dioxygenase (DAD). Gordon Research Conference on Enzymes, Coenzymes, and Metabolic Pathways (Waterville Valley, NH; July 22-27, 2018) – Poster

AY 16-17

Roberts, K. M. Oxidation by DAD: A novel reaction or an old dog with new tricks? USC Aiken Department of Chemistry and Physics (USC Aiken; March 31, 2017) – Invited Talk

Roberts, K. M., Weeks, J. A.*, Shores, V. M.*, Foerster, E. H.*, and Rowe, G. T. Characterization of 2,4’-dihydroxyacetophenone dioxygenase (DAD). Gordon Research Conference on Enzymes, Coenzymes and Metabolic Pathways 2016 (Waterville Valley, NH; July 24-29, 2016) – Poster

AY 15-16

Roberts, K. M. Reaction kinetics of phenylalanine hydroxylase. USC Aiken Department of Biology and Geology (USC Aiken; February 26, 2016) – Invited Talk

Roberts, K. M. Detection and identification of reaction products by continuous-flow/mass spectrometry. University of South Carolina Department of Chemistry and Biochemistry (Columbia, SC; January 19, 2016) – Invited Talk


GRANTS

AY 18-19

PI: White, D.  Laboratory Studies of Outer Planetary Ice Analogs Subject to Thermal Processing ASPIRE I, USC Office of the Vice President for Research. $15,000.  Funded, July 2019-Sept. 2020.

PI: Roberts, K. M. 2,4’-Dihydroxyacetophenone dioxygenase (DAD): metal-dependence and steady-state kinetics. RISE, USC Office of the Vice President for Research. $6,000. Funded, May-December 2019.

AY 16-17

PI: Leverette, C. L., Co-PI: Rowe, G. T., Marshall, N. M., Roberts, K. M., and Hancock, C. N. Acquisition of a liquid chromatography-mass spectrometer (LC/MS) for materials science and biochemical applications.  ASPIRE-III, 2017, USC Office of the Vice President for Research. $100,000. (July 2017-Sept 2018)

PI: Roberts, K. M. Anaerobic and oxygen-dependent studies of the mechanism of the 2,4’-dihydroxyacetophenone dioxygenase reaction. ASPIRE-I Track 1, 2017, USC Office of the Vice President for Research. $15,000. (July 2017-Sept 2018)

PI: Roberts, K. M. Validation of the proposed mechanisms for the 2,4’-dihydroxyacetophenone dioxygenase reaction. RISE, USC Office of the Vice President for Research. $6,000. (May-December 2017)